About University of Illinois, Chicago. University of Illinois, Chicago in Chicago, IL reports an overall acceptance rate of 77.3%, an SAT middle 50% of 1140–1330, a class size of 4,419, and a yield of 25.0% based on the most recent Common Data Set filings. Chicago's largest university and a top research institution. Strong health sciences, engineering, and architecture programs. One of most diverse campuses in the Midwest.